A Closer Look at Rejuran: What the Treatment Actually Does

Rejuran is a non-prescription regenerative skin therapy that uses polynucleotides – short strands of biological molecules – to support the skin’s own repair and renewal processes. It originated in Korean aesthetic medicine, where attention to skin quality, hydration and long-term skin health is more deeply embedded in clinical practice than in many Western markets.

Unlike treatments that fill, contour or relax muscles, Rejuran does not change the shape of your face. It works at the level of skin tissue, supporting the cellular processes that influence how your skin looks, feels and responds to its environment.

For clients who think of skincare as an investment rather than a quick fix, this distinction matters. Rejuran sits in a small group of regenerative treatments designed to improve the underlying quality of your skin, not just its surface appearance.

Polynucleotides are short biological molecules, similar in nature to the molecules your own cells use during repair and renewal. When delivered into the skin in controlled, measured amounts, they support three connected processes.

• Cellular repair – polynucleotides may help support the cells responsible for producing collagen, elastin and other structural elements of healthy skin.
• Hydration from within – they hold water at a deeper level than topical products can reach, supporting hydration that is built into the skin rather than sitting on top of it.
• Tissue regeneration – by encouraging the skin’s own renewal cycle, polynucleotides can support gradual improvement in texture, elasticity and radiance.

This is why the visible effect of Rejuran tends to develop slowly. You are not seeing a product that adds volume or smooths a line. You are seeing your skin gradually behaving as healthier skin behaves – more hydrated, more even, more resilient.

It is a meaningful shift in mindset: from chasing surface effects to supporting the systems that produce healthy skin in the first place.

Rejuran is most often considered when the goal is broader skin quality rather than a single, targeted change.

Common concerns it may help address include:

• dullness and uneven radiance
• skin texture irregularities
• early signs of skin ageing, particularly around fine lines and crepey areas
• dehydration that does not respond well to topical hydration alone
• a general sense that skin has lost its bounce, glow or resilience

Treatment areas may include the face, neck, decolletage and hands. Your practitioner will suggest a particular sequence based on your skin condition, lifestyle and history. The approach is built around your skin, not around the product.

If your priority is to add visible volume, soften deep static wrinkles or replicate what surgery does, Rejuran is not designed to deliver those outcomes. It complements other treatments rather than competing with them.

Every Rejuran treatment at Nano Aesthetics begins with a thorough consultation. Your practitioner reviews your skin, your health history and your goals – and shares an honest assessment of whether Rejuran is likely to suit you. If it is not, they will say so.

A typical Rejuran appointment takes between 30 and 60 minutes, depending on the treatment areas. Many clients describe the sensation as a series of small pinches; precise technique helps minimise discomfort.

After the session, most clients experience 1 to 3 days of mild redness, slight swelling or sensitivity at the injection sites. These responses are usually well tolerated, and your practitioner will provide tailored aftercare guidance, including recommendations to avoid harsh exfoliants, direct sun exposure and irritating products during recovery.

Results develop gradually. You may notice improved hydration and a softer skin texture within a few weeks, with cumulative changes building over a course of treatments. A personalised plan typically includes a series of sessions followed by maintenance, scheduled to support skin quality over time.

We talk openly about what each treatment can and cannot achieve, because integrity matters more than promises.

Rejuran is not designed to:

• replace volume that has been lost in the cheeks, lips or jawline
• soften deep, static wrinkles caused by long-term muscle movement
• deliver instant or dramatic transformation in a single session
• substitute for sun protection, sleep or a considered everyday skincare routine

It is also not suitable for everyone. Rejuran is not appropriate for people who are pregnant or breastfeeding, who have active skin infections, or who live with certain dermatological or medical conditions. Suitability is always assessed during your consultation.

Results vary from person to person. The most we can offer, honestly, is a treatment plan grounded in evidence, paired with a practitioner who knows your skin.

In Perth, late autumn and winter often create kinder conditions for regenerative skin treatments.

Sun exposure is lower, which suits a recovery period when skin should be protected from UV. Indoor heating can leave the skin a little drier, so any treatment that supports hydration from within tends to feel especially welcome at this time of year. Most importantly, May to August offers enough time for a course of sessions to develop their cumulative effect well before the warmer, brighter months return.

For clients who think long term, this is the natural moment to begin a skin investment plan rather than wait until results are needed for a particular event.

Whether Rejuran fits your skin goals depends on what you are looking for, and where your skin is now. The most useful next step is a personalised consultation: a relaxed, unhurried conversation about your skin history, your goals and the options that may suit you. There is no obligation to proceed with treatment.

If you would like to explore whether Rejuran could be part of your skin plan this season, we would be happy to talk it through with you in person. A consultation is the place to start – and the most honest way to find out whether this is the right fit for you.

Nano Aesthetics – Aesthetic Clinic, Joondalup
Book: nanoaesthetics.au | Phone: 08 6288 8628

Mia Kim, RN – Senior Cosmetic Injector | Co-Founder of Nano Aesthetics.
Bachelor of Nursing (UTS, 2011), Graduate Certificate in Contemporary Nursing. Mia draws on more than 5,000 aesthetic treatments and ongoing professional development across regenerative therapies, injectables and skin devices, alongside direct connections to the Korean beauty market. Her practice focuses on subtle, natural-looking outcomes and skin-health-led care.

Published: May 2026